I can definitely state that during the last three months that I have been taking OPC_3, I have noticed a sharp increase in my energy level. I am also witnessing an increased appetite and agreeable attitude. Since my last physical exam I am seeing improvements in lipid and comprehensive metabolic profiles. All of these improvements are, I believe, directly traceable to the time three months ago when I began using OPC-3. Thanks again Nan for introducing me to this great product.